As the error message indicated, it requires IIS integrated pipeline mode. Please select the application pool in IIS Manager, Click "Basic Settings..." and make sure "Integrated" mode is selected for "Managed pipeline mode" in the dialog.

You will also get the same error if you are trying to write or clear the headers.  In these cases use Response.AddHeaders() and Response.ClearHeaders() instead of Response.Headers["key"] = "value"
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